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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
The effects of ER once-weekly have been compared to exenatide twice-daily and overall ER was more effective at improving glycemic control and caused less gastrointestinal side-effects although both compounds caused a similar degree of weight loss (Drucker et al., The efficacy of once-weekly ER (2 mg) was compared to that of once-daily liraglutide (1.8 mg) in a 26-week trial in T2DM patients (Buse et al., DPP-4 inhibitors The DPP-4 inhibitors mediate their action by inhibiting the enzyme DPP-4, which prevents the breakdown of GLP-1 and thereby increases endogenous GLP-1 levels
Unfortunately, GLP-1 can decrease with age and lifestyle
conducted a pre-specified cardiovascular meta-analysis that included all seven randomized controlled trials with a duration of at least 26 weeks from the SURPASS trials [61]
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