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The hair shedding associated with GLP-1 class medications, including retatrutide, is primarily caused by the metabolic stress of rapid weight loss , not by direct drug toxicity to follicles

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A circumference greater than 40 inches in men, or 35 in inches in women is a rough indicator

Most individuals in this weight range will find their optimal maintenance dose between 8 and 12 mg

Similarly, in non-human primates, GLP-1 receptor agonists including semaglutide have been shown to suppress alcohol intake (Suchankova et al