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The protocol used in this research could be improved for future researches

[38] There are some reports that mammalian cells can take up extracellular NAD + from their surroundings, [39] and both nicotinamide and nicotinamide riboside can be absorbed from the gut

Any handling or storage should be treated with the same level of care that would be applied to other sensitive laboratory reagents

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A clear benefit in HRQoL was not demonstrated based on the included studies, and with a lack of additional evidence regarding outcomes such as diabetes-related morbidity beyond the CVOT, or a direct comparison to semaglutide injection