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Regulatory Status Disclosure: The FDA declared the semaglutide drug shortage resolved in February 2025 and the tirzepatide drug shortage resolved in October 2024

injections of 100 nmol kg 1 GLP-1MK-801, 10 nmol kg 1 semaglutide or vehicle (isotonic saline) based on baseline running wheel distance measurements, such that each group had similar average running wheel distances at the day of study initiation

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