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Key results: 12 mg dose: Average weight loss of 24.2 percent of body weight 8 mg dose: Average weight loss of 22.8 percent 4 mg dose: Average weight loss of 17.0 percent Over 90 percent of participants at 8 or 12 mg lost at least 10 percent of body weight Over 75 percent at 12 mg lost at least 20 percent Crucially, the weight loss curve had not yet plateaued at 48 weeks, suggesting longer treatment may produce even greater results
14 Both studies were limited by relatively short follow-up among the included trials, narrow systemic inclusion criteria, limited information on baseline diabetic retinopathy status and, most important, inadequate and non-rigorous methodologies for diabetic retinopathy evaluation
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