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administered five potentially probiotic strains supplemented with 1.3% choline to mice, they found that Lactobacillus plantarum ZDY04 can decrease serum TMAO and cecal TMA levels by modulating the relative abundance of the families Lachnospiraceae , Erysipelotrichaceae and Bacteroidaceae and the genus Mucispirillum (Qiu et al., 2018)

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In the first group, after three months of treatment, we noted poor clinical response in most of cases