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The substance has been tested for topical use in cosmetics, but injection trials have been limited to rats, mice, dogs, in vitro cells, and lungs removed from transplant patients

(PubMed) Arai H, Kono N

The authors wish to sincerely thank Yukiko Lema for assistance

Since systemic oxidative stress is increased in patients with melasma, serum levels of melatonin and catalase are significantly lower [68]

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