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Importantly, absolute rate reductions for all effectiveness outcomes were larger with increasing severity of frailty. Researchers conducted a retrospective cohort study of older adults aged at least 65 years diagnosed with type 2 diabetes who initiated an SGLT2 inhibitor, GLP-1 receptor agonist or a DPP-IV inhibitor

Because there have been concerns, particularly about psychiatric adverse events including depression and suicidality

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They typically had shorter duration of obesity before treatment

[24] [25] Clinical decision-making should therefore integrate general prescribing principles with haematology-oncology considerations