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Today it is available only by prescription, compounded by state-licensed 503A pharmacies or FDA-registered 503B outsourcing facilities, neither of which is independently reviewed or approved by the FDA as a finished drug product, most commonly prescribed off-label for adult GH decline or wellness/anti-aging use

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Once inside adipocytes and other metabolically active cells, the compound binds to the NNMT active site, preventing the enzyme from converting nicotinamide to 1-MNA