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If your appetite suppression has noticeably weakened, if food noise has returned to pre-medication levels, if you can eat larger meals without discomfort, and if the characteristic feeling of the medication has faded, these point toward receptor level changes rather than simple metabolic adaptation

PubMed ID: 17018654 Alba M et al

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Direct usage of vitamins of Classes A, D, E, K, and B12 may be a useful path to correcting metabolic and hormonal imbalances in PCOS