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This dual mechanism produces greater effects: clinical trials show tirzepatide produces approximately 2.0-2.3 percentage point reductions in HbA1c (versus 1.5-1.8 for semaglutide) and 15-22% weight loss (versus 10-15% for semaglutide)

Note that 100mg vials at daily 2mg dosing provide 50 days of product, which exceeds the 30-day reconstituted stability recommendation

Prioritizing lifestyle interventions remains fundamental

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The randomization was scheduled using SAS programming code