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Adjustment strategies relied on measured confounders such as HbA1c and BMI but could not fully account for time-varying confounding by indication

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This raises an important question: do these benefits extend to nonhabitual consumers, and can they be achieved at lower, more realistic daily doses

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[1] [2] A 2011 Cochrane review showed a HbA1c reduction of 0.20% more with exenatide 2 mg compared to insulin glargine, exenatide 10 g twice daily, sitagliptin and pioglitazone