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There is one retrospective chart review of sixteen patients with chronic knee pain who paid for intra-articular injections

Some can speed up the metabolism of contraceptive hormones, reducing their levels in the bloodstream

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doi: 10.1016/j.clinbiochem.2012.11.021 96 ErdamarHDemirciHYamanHErbilMKYakarTSancakBet al

When combined with PDGF, a statistically significant increase in both proliferation and calcification was noted [104]