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Imaging and biomarker endpoints The sharpest biomarker lesson from this literature comes from a negative trial

These reports represent a fraction of total patients using compounded tirzepatide, but they demonstrate that the risk is not theoretical

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All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes

Lancet 394, 3950