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Symptoms of AVED usually manifest early in life (ages 5-15 years)

TLRs can be localized either on the cell surface (TLR-1, -2, -4, -5, -6, -10) or in the endosome compartment (TLR-3, -7, -8, -9

Since oxidation participates as an essential messenger of cellular signaling pathways, treatment of oxidative stress needs to consider maintaining that physiologic threshold (230, 231)

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