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For example, in SAVOR-TIMI 53, saxagliptin use was associated with slowing in the rate of progression of albuminuria in patients with and without CKD

Serious/Rare Risks: Pancreatitis, gallbladder issues (a known risk with rapid weight loss), and modest increases in resting heart rate

Clinical data shows average A1C reduction of 2.02% in participants with diabetes, triglyceride reduction of 28%, systolic blood pressure reduction of 6.8mmHg, and LDL cholesterol reduction of 12%

Shortly after these guidelines were released, the British Association of Anaesthetists released guidelines in January 2025 with similar recommendations