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Constitutive activation of NRF2 has been considered as a resistance mechanism to chemo or radiation therapy because the NRF2-mediated antioxidant response eliminates therapy-induced ROS, thereby promoting cell survival

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Proteomics 10, 129

The benefits will gently fade

For general health and maintenance, a daily dose of 500-2,000 mg is typically recommended

The cytosolic glutathione pool influences the Mia40 redox state The possibility of reversible disulphide bond formation in the IMS is supported by the effects of varying E GSH [IMS] on the redox state of Mia40 (Figure 9B)