Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8 cells, thereby inducing + T apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis
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Lei, X.-Q
Opioid analgesics like morphine activate -opioid receptors which can trigger pro-survival signaling in heart and also reduce sympathetic tone (lowering metabolic demand)
Nature 499 , 444449 (2013)
Sulhan et al., 2020), leading to a sharp increase in intracranial pressure and eventually cerebral hernia (Winkler et al., 2016)