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Molestias digestivas (las ms comunes) Nuseas: entre 20% y 44% de los pacientes (ms comn al inicio y con dosis altas) Vmitos: entre 10% y 24% Diarrea: entre 12% y 30% Estreimiento: entre 6% y 24% , segn la molcula y la duracin En general, 4 a 7 de cada 10 pacientes (40-70%) presentan algn sntoma digestivo durante el tratamiento, sobre todo en las primeras semanas, con tendencia a mejorar con el tiempo (1,8-11)