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2 The FDA approval of Wegovy HD is based on the results of the STEP UP trial program, which included STEP UP, a 72-week study which evaluated the efficacy and safety of once-weekly Wegovy 7.2 mg compared to placebo and Wegovy 2.4 mg, as an adjunct to lifestyle intervention in 1,407 adults with obesity (BMI 30 kg/m 2 or greater), without diabetes

Knockout of insulin receptor in mice results in slight growth retardation at birth, but no metabolic abnormalities are present

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Research Purposes Only