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Key genetic variantsincluding GLP1R rs6923761 and GIPR rs1800437determine how many GLP-1 and GIP receptors your cells express and how sensitively they respond to the medication

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Back Zander, M, Madsbad, S, Madsen, JL, Holst, JJ (9 March 2002) 'Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study', The Lancet , 359/9309, 824-30

Verify new semaglutide dose within licensed range or document rationale for off-label use