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Targeting Nrf2 ubiquitination to mediate ferroptosis in lung cancer The high expression of Nrf2 is essential for the survival of lung cancer cells, thus strategies to reduce Nrf2 expression may be effective for the treatment of lung cancer, in which ubiquitination plays an important role in the Nrf2 protein degradation pathway

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Research participants on semaglutide at maintenance doses showed an average of 15 to 17% body weight reduction over 68 weeks in the landmark clinical trials