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While nicotinic acid (a form of niacin) can cause flushing at high doses and B6 can lead to nerve issues if taken in massive amounts for very long periods, the amounts found in multivitamins are far below those thresholds

Higher proportions of patients (58%) randomized to CagriSema reported gastrointestinal (GI) adverse effects compared with those who received cagrinlitide (33%) and semaglutide (32%)

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The pathomechanisms, which are studied in the scope of clinical trials, are supported by the in vivo models

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These data together suggested that erastin-resistant cells adapted to erastin insult through a mechanism to rebuild up GSH homoeostasis