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10.3402/ljm.v9.23055 [DOI] [PMC free article] [PubMed] [Google Scholar] 38.Solverson KJ, Lee H, Doig CJ

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The pharmacology assumes continued use

Mechanisms reported in the literature include: GLP-1 receptor activation Stimulates glucose-dependent insulin release Supports appetite regulation and satiety signaling Slows gastric emptying GIP receptor activation Augments insulin secretion Associated with -cell support and improved nutrient handling Glucagon receptor activation Linked to increased energy expenditure Promotes hepatic lipid mobilization and oxidation Clinical Research Evidence In a published Phase 2 randomized trial, retatrutide produced dose-dependent reductions in body weight, with the highest dose associated with up to approximately 24% mean body-weight reduction at 48 weeks , alongside improvements in cardiometabolic markers

Confusingly, the December 2024 South African package insert states the following: This reduction in exposure after a single dose of MOUNJARO is not considered clinically relevant