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Loffredo, L., Pignatelli, P., Cangemi, R., Andreozzi, P., Panico, M

Read it here: To view or add a comment, sign in LetterJune 11, 2026 Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate Robert E

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A pooled analysis of the STEP 1-3 trials (n=2,117 semaglutide 2.4 mg, n=1,262 placebo) reported GI adverse events in 72.9% of the semaglutide group versus 47.1% of placebo, with nausea (43.9% vs 16.1%), diarrhea (29.7% vs 15.9%), vomiting (24.5% vs 6.3%), and constipation (24.2% vs 11.1%) the most common categories