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GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptors enhance insulin secretion and appear to improve fat metabolism

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Changes in mitochondrial morphology have been previously associated with modified nutrient utilisation, with a strong correlation between mitochondrial fragmentation and increased lipid utilisation via fatty acid oxidation (FAO) 74 , a process inhibited in -cells under high glucose conditions to favour metabolic coupling towards insulin secretion 73,75 that could potentially be modulated by the GLP-1R under excess lipids to enable lipid clearance and detoxification 73