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The primary outcome measure was overall response rate according to Response Evaluation Criteria In Solid Tumors (RECIST, version 1.1) criteria as assessed by blinded independent central review.[1][Level of evidence B3] The overall response rate was 26% (95% confidence interval [CI], -14 to 13

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Along with the direct activation of matrix metalloproteinase-2 (Bescond et al, 1999), vascular damage might also result from an impairment of the tertiary structure of connective tissue protein, because of the reduced degree of cross-linkage between collagen and fibrin monomers (Lubec et al, 1996a

8e,f), suggesting that -KG competitors similarly inactivate AMPK and disable energy sensing in human cancer cells

Children Pediatric patients (i.e., between 3 months and 10 years) have 50% higher clearances expressed on weight (i.e., mL/min/kg) than do adults

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