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A (retinol), Zinc, and Selenium ( N = 2,603428,860) were significantly associated with independent single-nucleotide polymorphisms (SNPs)

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While the exact mechanism isn't fully understood, headaches likely result from dehydration due to gastrointestinal side effects, blood glucose fluctuations, or metabolic changes during treatment initiation

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Not to mention: the astronomical cost of medical services and medication

JAMA Intern Med 177(5):633640