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Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo

These include inhaled adrenergics such as the beta-2 agonists (Ventolin), inhaled corticosteroids (Azmacort), and intranasal steroids used for allergic rhinitis (Flonase, Vancenase), or any other medication that attains poor or short lasting plasma levels

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Studies show that even partial sleep restriction for one week increases CRP levels and shifts immune cell populations toward a more inflammatory profile