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Nevertheless, oral semaglutide performs significantly better than placebo and better than subcutaneous liraglutide: the PIONEER 4 study shows that oral semaglutide 14 mg led to 4.4 kg of weight loss versus 3.1 kg with subcutaneous liraglutide

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One overnight temperature excursion, one week of light exposure, one reconstitution with the wrong water can reduce a $200 vial to an expensive placebo