Recommendation for oral semaglutide (Wegovy pill, Rybelsus): Avoid breastfeeding
The ingredients are not new
Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial
Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, et al
All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes
Post-discontinuation, 19.6 % restarted the original medication, while 35 % adopted another option: alternative medication (27.4 %), healthcare visit for lifestyle modification (13.7 %), and metabolic and bariatric surgery (0.6 %)