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They are metabolised and eliminated through different pathways: semaglutide is broken down by proteolytic enzymes (similar to endogenous proteins) and does not rely on cytochrome P450 liver enzymes, whilst topiramate is partially metabolised hepatically but largely excreted unchanged in urine

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Novo Nordisk's combined expertise in GLP-1 and amylin chemistry enabled this approach

AASD position statement Hypoglycemia should be considered as a potential cause of any alteration in consciousness

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Focusing on lean protein helps preserve muscle mass as you lose fat, which is essential for keeping your metabolism high