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Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles

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Growth hormone is a powerful regulator of body composition

While compounded GLP-1 medications may use the same active pharmaceutical ingredients found in branded drugs, the FDA does not review compounded formulations for safety, efficacy, or manufacturing quality in their final form

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Gut 58 , 10911103 (2009)