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have been focused on improving diversity in clinical trials for at least 30 years and a dramatic increase in reporting of diversity data has occurred over the past five years Based on race/ethnicity data reported, both Black/African American and Hispanic participation in trials fall short of 2020 U.S

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In summary, we have demonstrated that a single amino acid replacement of leucine-973 in the juxtamembrane region of IR to phenylalanine, which is the equivalent residue in the IGF1R, is sufficient to lead to a decrease of IRS-1/PI3K/Akt/mTORC1 signaling and an increase of Shc/Gab1/MAPK cell cycle signaling

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