On the kidneys, a pooled analysis of Phase 2 obesity and type 2 diabetes data showed reductions in the standard kidney-injury marker (the urine albumin-to-creatinine ratio, or UACR) of approximately 37% in adults with type 2 diabetes and 31.5% in adults with obesity but no type 2 diabetes, both on the 12 mg dose [12]
Charles River) were used for T2D rat studies for evaluation of long-term pharmacokinetics and bioavailability of the GLP-1 RA hydrogel formulations under Stanford Administrative Panel on Laboratory Animal Care protocol #32873
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Cells were seeded in 96-well MicroWell round-bottom plates (Thermo Fisher Scientific)
Yoo HJ, An HG, Park SY, Ryu OH, Kim HY, Seo JA, et al
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