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KPV, by contrast, is a short tripeptide fragment derived from the alpha-melanocyte stimulating hormone sequence that retains key signaling properties of the parent melanocortin peptide, allowing researchers to investigate inflammatory signaling pathways and epithelial barrier biology in controlled laboratory systems

and NVXCoV2373, Novavax), which were also based around ancestral sequences

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation

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