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To do this, you pinch up an area of skin with your thumb and forefinger, and then push the needle of the pen into this area, so that the medication will be injected just under the skin

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Huang Z, Liu L, Zhang J, Conde K, Phansalkar J, Li Z, et al

[12] [13] This occurs because the medication's effects on appetite suppression, satiety, and metabolic rate cease once the drug is cleared from the system