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doi:10.1074/jbc.REV120.012411

Tirzepatide, Retatrutide, and Breniperatide all remind me of Exenatide, the peptide famously discovered in the saliva of a lizard

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Similarly, environmental enrichment, which provides enhanced sensory, cognitive, and motor stimulation, can elevate BDNF levels and, when combined with therapies that bolster TrkB expression (as demonstrated with the peptide P42 in an HD mouse model), synergistically delays disease progression and improves motor and cognitive outcomes (Couly et al., 2021)

Metformin lowers -synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinsons disease