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Many also suffer from chronic constipation

1988 May;85(10):3653-6

The things we do with our minds affect the body and vice versa

therefore, prescribers usually restrict use to adults unless compelling justification exists

Source: NCBI 9.3 Million In 2020, 3.3 percent (about 9.3 million individuals) reported misusing prescription pain drugs in the past 12 months

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization