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At 24 h, no regulation was observed in HepG2 cells, but HepG2 ATP7B-KO cells showed a dose-dependent reduction, with 0.6mmol/l CuCl reducing promoter activity by 50.76%

Likewise, GIP receptor antagonists have been reported to induce weight loss in animal studies

doi: 10.1016/j.fsi.2017.11.043

If your experimental design doesnt account for enzymatic degradation, your results will be all over the place

Decreased GSH levels have been shown to activate NF-kB, further impairing mitochondrial function and creating a vicious cycle

It is always a good idea to start with a smaller dose to see how your body reacts and to consult with your healthcare provider if you have concerns or are taking other medications