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Phen-Fen (phentermine + fenfluramine) was the GLP-1 of its day effective for weight loss, but discontinued in 1997 for causing heart-valve damage and pulmonary hypertension

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Adv Healthc Mater 12:e2203362 Yang WS (2023) Ferroptosis: whERe is the critical site of lipid peroxidation

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However, absence of extensive research on newer variants does not mean they are ineffective, just less studied

If a treatment is pro-growth, that should be part of the conversation