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However, minor structural modifications between the hexapeptide chains yield profoundly distinct adverse effect profilesmost notably regarding ghrelin mimicry and hunger signaling

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Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)

Sep 2012;38(9):1182-6