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These free radicals can be generated through environmental factors such as UV exposure, pollution, and smoking

[DOI] [PubMed] [Google Scholar] 42.Kalume F., Westenbroek R.E., Cheah C.S., Yu F.H., Oakley J.C., Scheuer T., Catterall W.A

Inhibition of Autophagy Kinase ULK1 Combined with Chemotherapy Results in Modulation of Reactive Oxygen Species and DNA Damage Response to Induce Synergistic Cell Death in Acute Myeloid Leukemia

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Wiser et al., 2010