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In a clinical trial published in JAMA and The New England Journal of Medicine , semaglutide tripled weight loss for participants who received lifestyle management coaching

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While these agents are effective in earlier stages of diabetes, they can become dangerous in end-stage kidney disease (ESKD)

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Common adverse effects include nausea, vomiting, diarrhoea, abdominal pain, and constipation, affecting a substantial proportion of users according to UK SmPCs