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The Bottom Line Tirzepatide produced greater average weight loss than semaglutide in a direct 72-week obesity trial, but that does not make tirzepatide automatically better or semaglutide automatically safer

As such, a typical course usually runs for 3 to 6 months

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Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, represents the next generation, and the retatrutide calculator supports dosing for those exploring that compound

doi: 10.1159/000541881 177 DaiJLuYRocaHKellerJMZhangJMcCauleyLKet al