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Recognition of pathogens, particularly bacteria and fungi, has been shown to prompt GABA accumulation in several plant species

Arch Dermatol 1982

Additional studies have explored activation of focal adhesion kinase (FAK) and paxillin pathways in fibroblasts, which are involved in cellular migration, extracellular matrix interactions, and structural tissue dynamics [2]

As the disease progresses, the overlying skin can be thicker and distorted

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Jurkov, M., Danihel, , Polk, & Varga, I