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doi: 10.1186/1471-2261-12-10

In research settings, it is studied for its apparent role in tissue repair, angiogenesis, nitric oxide system interactions, and musculoskeletal healing mechanisms in vitro and animal model studies

Rossi, R., Giustarini, D., Milzani, A

Over-expression of miR-17-92 in HUVECs can protect ECs from erastin-induced ferroptosis by targeting the zinc lipoprotein (A20)-acyl-CoA synthetase long-chain family member 4 (ACSL4) axis that could protect glutathione peroxidase 4 (GPX4) and inhibit ROS production (Xiao et al., 2019)

In high salt-treated DSS rats, supplementation with NAC diminished renal NADPH oxidase activity and expression, and lowered urinary levels of H 2 O 2 and 8-isoprostanes, a marker of lipid peroxidation (27)