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The clone with an R121S substitution showed the best activity and was named G1 (Supplementary Fig

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As low levels of GH/IGF were also reported to delay puberty and reproduction in KO models, it seems feasible that this axis may be working by shifting a biological timer and delaying aging as a consequence, which may defer as well the arrival of age-related diseases (253)

MDA-MB-231 (female, ATCC Cat# HTB-26), MCF-7 (female, ATCC Cat# HTB-22), HeLa (female, ATCC Cat# CCL-2), A549 (male, ATCC Cat# CCL-185)

(39) and Sirdah et al