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Furthermore, PLC- isoforms are involved in some physiological conditions such as epilepsy, abnormal functioning of neutrophils and platelets, hyper-responsiveness to opioid stimulation, ataxia, and impairment in visual perception (Vines, 2012)

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Conversely, urate-like antioxidants produced in the hemolymph were found to arrest epimastigotes' growth and promote differentiation of epimastigotes to metacyclic infective form (Nogueira et al., 2015)