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The orthopaedic surgeon or general practitioner may start symptom relieving medications until the patient has been assessed and referred to a rheumatologist Researchers are also working on biologic agents that can interrupt the progress of the disease

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Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor - and interleukin-1-induced IKK/NF-B and JNK/AP-1 activation